这两个词语意思相同，均表示：无论如何、不管怎样（接副词或形容词）、然而、可是。两者基本可以通用，但是however的内涵更多，用法更灵活，nevertheless使用使用范围较窄。
however例句：
1、He can answer the question however hard it is.
不管问题有多难他都能回答。
2、However did you get here?
你是怎么到这里来的?
3、He hasn't arrived. He may, however, come later.
他还未到，不过，他可能过一会儿来。
4、"I'd like to go with you; however, my hands are full."
"我很想和你一块儿去,可是我忙不过来。"
nevertheless例句：
1、She was very tired, nevertheless she kept on working.
她虽然很疲倦，可仍在继续工作。
2、He's stupid, but I like him nevertheless.
他是很笨，然而我喜欢他。